Low serum C4 concentrations: an inherited predisposition to insulin dependent diabetes?

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Low serum C4 concentrations: an inherited predisposition to insulin dependent diabetes?

Twenty two out of 86 insulin dependent diabetics had serum C4 concentrations below the normal range. None of 41 non-insulin dependent diabetics tested had low concentrations. Low C4 values were seen in insulin dependent diabetes irrespective of the duration of the disease and did not appear to correlate with complement activation. There was a close correlation in C4 values between identical cot...

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Plasma C4 concentrations were measured in insulin dependent diabetics with and without microangiopathy and in controls. The diabetics had significantly lower C4 values than controls (p less than 0.001), and patients with insulin dependent diabetes and microangiopathy had lower values than those without this complication (p less than 0.001). There was a 7.1-fold increase in the prevalence of com...

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ژورنال

عنوان ژورنال: BMJ

سال: 1983

ISSN: 0959-8138,1468-5833

DOI: 10.1136/bmj.286.6369.926